Injectables and Cell Therapies for Cartilage Repair/Osteoarthritis: Clinicians and Scientists Working Together to Understand Mechanism and Improve Stratification
Chair: Ines Reichart, Co-Chair: Karina Wright
This session will explore the current injectable and surgical approaches used in the treatment of cartilage injuries and osteoarthritis, with a particular focus in the knee:
Interventions covered will include hydrogels, blood and bone marrow derived biologics as well as advanced therapy medicinal products (ATMPs), including autologous chondrocyte implantation (ACI).
An understanding of the changing regulatory landscape pertinent to these interventions is key and will be reviewed.
The process and challenges of undertaking a clinical trial to evaluate efficacy will be explored.
Exemplars describing how clinicians and scientists can work together to better understand mechanism and improve stratification of treatments will be presented.
Agenda:
10:30 – 10:50 Introduction Professor David Johnson
10:50 – 11:10 Current Surgical Options and Injections Paul Jermin
11:10 – 11:30 Trials and Tribulations James Murray
11:30 – 11:50 Scientific Study of Mechanism and Stratification Professor Karina Wright
11:50 – 12:00 Open Discussion and Round-Up All
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Paul Jermin
Consultant Knee Surgeon/ Hon Sen Lecturer Trauma & Orthopaedic Surgery , RJAH Orthopaedic Hospital (Oswestry)
Paul Jermin is an elective knee surgeon working in the RJAH Orthopaedic Hospital Foundation Trust (Oswestry). He has a special interest in early OA and regenerative procedures.
Paul is also an honorary Senior Lecturer at the University of Keele, Director of Medical Education at Oswestry. Paul has recently founded and runs the monthly National Complex Cartilage meeting. He is also a current Christan Bezenar Fellow.
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David Johnson
Consultant Knee Surgeon / Professor of Trauma & Orthopaedic Surgery, Stepping Hill Hospital, Stockport
David Johnson has been a consultant at Stepping Hill Hospital, Stockport since 2001 where he has a practice in knee surgery. He also treats children with knee injuries and has an interest in recurrent patellar dislocation along with patellofemoral osteoarthritis. He is actively engaged in research supervising trainees, along with projects at both the Universities of Manchester and Salford where he holds honorary contracts.
He is currently Chair of the Greater Manchester Orthopaedic Alliance. In this role he is engaged with the Manchester Academic Health Science Centre and Health Innovation Manchester to aid translation of research into clinical practice. He is a Member of the British Orthopaedic Association, the British Association for Surgery of the Knee and the British Patellofemoral Society.
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James Murray
Consultant Orthopaedic Surgeon, Lead for Knee Surgery, Avon Orthopaedic Centre Southmead Hospital, North Bristol NHS Trust
James Murray started his practice as an orthopaedic consultant in Bristol in 2007. He holds an elective NHS Consultant post at The Avon Orthopaedic Centre in Southmead Hospital, North Bristol NHS Trust, where he is the Specialty Lead for Knee Surgery and Co-Lead of the Regional Knee Network, previously having been Director for Elective Orthopaedics 2017 – 2020 and Director for Trauma from 2008-2012. James is an Honorary Lecturer at the University of Bristol Medical School.
James has a keen research and training interest having written numerous published peer-reviewed papers (91) and one book, A to Z of Musculoskeletal and Trauma Radiology.. He is also a current reviewer for scientific journals, including the Bone and Joint Journal and The Knee, having previously reviewed for Injury, Acta Orthopaedica and Clinical Orthopaedics and Related Research. James leads on a number of trials and contributes to others as a co-investigator; he works closely with his colleagues as a member of the Bristol Knee Group which carries out research and teaching related to knee surgery both in the UK and internationally. He is a member of both national (BASK Working Groups for Meniscus, Injury Prevention, Joint Preservation, Multi-ligament Injury, Primary Arthroplasty and Revision Knee Surgery) and international collaborative.
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Ines Reichert
Consultant Trauma & Orthopaedic Surgeon, King's College Hospital NHS Foundation Trust
PhD in Fracture Healing and Bone Blood Flow at Imperial College prior to her Orthopaedic Training in the KSS / South-East London Region. Since continued interest in research with focus on fracture treatment, post-traumatic OA and the effect of comorbidities, in particular diabetic neuropathy, on bone biology. Clinical Research: conduct and delivery of NIHR portfolio trials, Undergraduate teaching. Active member of BORS, ORS / ISFR. Clinical Sub-specialities Hand & Wrist / Diabetic Foot / Trauma.
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Karina Wright
Professor of Orthopaedics and Bioengineering (BORS Treasurer Elect) , Keele University/RJAH Orthopaedic Hospital (Oswestry)
Karina Wright is a basic scientist, based at the Keele laboratories in the Robert Jones and Agnes Hunt Orthopaedic Hospital Foundation Trust, Oswestry. She started her PhD there in 2005, studying cell therapy mechanisms in spinal cord injury. She is a Professor of Orthopaedics and Bioengineering and the Director of Keele’s Centre for Regenerative Medicine Research (launched last year). She leads modules in the Schools of Pharmacy and Bioengineering and Life Sciences on Applied/Translational Regenerative Medicine.
Her laboratory group at the RJAH develops and tests novel biological therapies for orthopaedic patients. Her team’s research transcends the bench to bedside translational pipeline, from in vitro analyses, organ-on-a-chip systems, pre-clinical models, clinical trials and finally NICE approved treatments. They are equally interested in learning from bedside to bench through reverse translational research, by collecting and analysing human cells and tissues and relating biological profiles to clinical outcomes in an effort to refine, tailor and develop novel treatments.